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Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism

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Age-Related Cognitive Decline: In aged rats (24+ months), Dihexa improved performance on both spatial memory and novel object recognition tasks

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