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Flament, H

First, both drive disease progression through chronic inflammation: senescent cells secrete the pro-inflammatory chemokines and cytokines (e.g., IL-6, IL-8) to trigger inflammaging, 103 while cancer cells and stromal cells in the tumor microenvironment release pro-inflammatory factors via similar mechanisms, forming immunosuppressive inflammation 138

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Chem Biol Interact 2019;310:108754

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Once stabilized, treatments may be spaced every 24 weeks for maintenance