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In a clinical study of mice, retatrutide and tirzepatide had superior efficacy in improving diabetic kidney disease, blood sugar control, and weight loss

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Mounjaro was first approved by the FDA in May 2022 to treat type 2 diabetes, and Zepbound was approved by the FDA in November 2023 for long-term weight loss in adults with both obesity and either diabetes or an increased risk for a cardiovascular condition

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