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As well, in real-world scenarios, such as described by Brindisi et al, it is mentioned a reduction in pleasure and taste perception in overweight and people with obesity with poor type 2 diabetes control, probably by lowering the detection threshold of sweet flavors, becoming more sensitive to them, resulting in aversion for this flavor (175)
Its also important for the kidneys to filter out toxins so they can leave via urine, the lungs to help you exhale toxins and the skin releases toxins via sweating
Its safety profile is yet to be defined through continued clinical trials and real-world reports