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consistent ~12-15% weight loss at 68 weeks Compound Tirzepatide (Zepbound) Class GIP/GLP-1 dual agonist FDA Status FDA-approved for chronic weight management Evidence Strength Phase 3 RCTs

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In trials that meant about a 15% reduction over 26 weeks, while sparing subcutaneous fat and lean muscle

Clinical trials have shown average weight losses of: Up to 15% of body weight with semaglutide (Wegovy) 1022% with tirzepatide (Mounjaro), according to JAMA But remember, these results were achieved with: Ongoing use of the medication Calorie-controlled diets Regular physical activity Behavioral support Some people choose to complement treatment with doctor-approved nutrition and lifestyle changes