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3.3 Protein damage and the stress sensing Cells convert heat-induced protein damage into a regulated transcriptional signal through a competitive release mechanism in which the dissociation of HSF1 from inhibitory chaperone complexes serves as a central switch in the stress response (Figure 2a) (Zheng et al., 2016)

Morris, C.R., HamiltonReeves, J., Martindale, R.G., Sarav, M