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Another potent oral PARP1/2 inhibitor, niraparib (MK4827) binds to the active site of PARP enzymes, and studies indicate that Niraparib can restore NAD + levels and improve mitochondrial function 165,166

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Another study, using dulaglutide, reported a medium-to-large effect size for reducing alcohol use in people with obesity, although no benefit was seen in heavy drinkers [35]

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The future of lifestyle drugs GLP-1s proved that therapies addressing conditions once dismissed as cosmetic or lifestyle-driven can deliver transformative medical and commercial impact

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