NNMT expression is significantly upregulated in white adipose tissue during obesity (3-5 fold) and increases with age across multiple tissues, creating a metabolic drain on both the NAD+ pool and the methylation budget
NNMT is an enzyme that methylates nicotinamide, a key NAD+ precursor, depleting cellular methyl donor pools and influencing both NAD+ availability and broader methylation pathways
Human studies have mainly focused on safety, how the body handles the peptide, and metabolic markers such as IGF-1 and glucose levels, but have not shown strong evidence of weight loss
Despite these concerns, GLP-1 injections are generally considered safe when prescribed and monitored by a healthcare professional
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