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Large observational studies have found that GLP-1 receptor agonists are associated with a lower risk of non-candida urinary tract infections compared to SGLT2 inhibitors, with a hazard ratio of 0.91 or lower and statistical significance below 0.001

Others restrict it to patients who have already tried lower-cost medications first

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Explaining metabolic adaptation helps normalize treatment plateaus and reduces discouragement

The drug creates a positive feedback loop where weight loss improves the metabolic environment, which makes further metabolic normalization easier

Association of bile duct and gallbladder diseases with the use of Incretin-based drugs in patients with type 2 diabetes mellitus