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Patients are generally considered eligible if they meet the following criteria: BMI of 40 kg/m or above , or BMI of 3539.9 kg/m with a significant obesity-related comorbidity such as type 2 diabetes, hypertension, obstructive sleep apnoea, or non-alcoholic fatty liver disease All appropriate non-surgical measures have been tried but have failed to achieve or maintain adequate clinically beneficial weight loss The patient is fit for anaesthesia and surgery The patient commits to long-term follow-up NICE CG189 also recommends that bariatric surgery should be considered as a first-line option for adults with a BMI over 50 kg/m, where surgical intervention may be more clinically appropriate than prolonged conservative management
Majzoub, Ahmad
Many patients report nausea, early fullness, and reduced appetite
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The transcytotic pathway, in contrast, involves calcium-dependent engagement of the cytoplasmic tail of FcRn by calmodulin, and is controlled by Rab25 and myosin VB [79, 80]
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