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The addition of glucagon receptor agonism introduces a third axis: increased energy expenditure, enhanced hepatic fat oxidation, and PCSK9-mediated reduction in LDL cholesterol

9 The Wegovy injection now has a higher 7.2 mg dose, approved by the MHRA on 6th January 2026, with a single-dose 7.2 mg pen following on 14th April 2026

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