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No cases of pancreatitis, thyroid C-cell tumours, or severe hypoglycaemia were reported in the Phase 2 cohort
Given the abundance of RBCs in blood, erythrocytes have been reported to produce up to 40% of thrombin in certain pathological conditions [47, 49, 50]
For diabetes cases with cardiovascular risk, the 2024 ADA Standards of Care explicitly state: "In patients with type 2 diabetes and established cardiovascular disease or indicators of high cardiovascular risk, a GLP-1 receptor agonist with demonstrated cardiovascular benefit is recommended independently of baseline HbA1c, individualized HbA1c target, or metformin use" [6]
It is all the more surprising that, although the link between diabetes and cognitive dysfunction was discovered more than 100 years ago and has imperative clinical significance, this complication of diabetes remains relatively poorly understood [28]
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