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The Food and Drug Administration (FDA) mandates that clinical trials demonstrate the cardiovascular safety of anti-diabetic medications
Stomach acid is necessary for making Vitamin B12 available from food
For instance, treating 20 type 2 diabetics with 35 mg PLP along with 3 mg activated folate and 2 mg vitamin B12 improved skin sensation in diabetic peripheral neuropathy (Walker 2010)
Nitric oxide pathways Modulation of nitric oxide systems involved in vascular function and tissue repair
While lifestyle changes and medications like statins remain the first line of defense, there is growing interest in regenerative therapies that may complement these approaches
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