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Based on the most recent data, the price-elasticity story mostly appears to change the shape of the uncertainty range around that $36.5 central estimate, rather than flipping it on its head

Mounjaro cardiovascular outcomes data is still pending (SURPASS-CVOT expected 2029)

While formal clinical trials of this specific combination await development, the theoretical basis for synergy is compelling, supported by successful precedents like CagriSema and the impressive individual performance of both compounds

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In a two-year extension limited to people with a BMI of 35 or higher, average weight loss reached 30.3% at 104 weeks

Although rates of acute pancreatitis have been low and similar between GLP-1 agonists and placebo in studies, caution is still warranted since acute pancreatitis carries a risk of recurrencewhich can turn into chronic pancreatitiswhich can increase risk of pancreatic cancer