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Schematic diagram of semaglutide absorption in the stomach following oral administration [5] Systemic regulation of GLP-1 RAs Apart from its ability to act on the pancreas to enhance glucose-stimulated insulin secretion (GSIS) and to inhibit the secretion of glucagon, GLP-1 RA can reduce body weight by decreasing homeostatic food intake, and GLP-1RA further delaying gastric emptying

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Continuous data are presented as the median (25th, 75th percentiles)

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