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When to contact your GP: Persistent or severe nausea/vomiting preventing adequate fluid intake Severe, persistent abdominal pain which could indicate pancreatitis New or worsening depression, anxiety, or suicidal thoughts Severe headaches or visual disturbances Unexplained cognitive changes or confusion Signs of hypoglycaemia (if taking alongside insulin or sulfonylureas) NICE guidance recommends regular monitoring during GLP-1 receptor agonist therapy

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Another study from UC Irvine recently validated that indeed GSH depletion precedes plaque deposition in transgenic AD mice [2]

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Therapeutic algorithms to treat neuropathic pain include molecules acting on 2 subunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways [13]

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