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After menopause, when estrogen remains consistently low, metabolism slows further

Semaglutide (Wegovy) typically follows this schedule: Weeks 1-4: 0.25 mg Weeks 5-8: 0.5 mg Weeks 9-12: 1.0 mg Weeks 13-16: 1.7 mg Week 17+: 2.4 mg (maintenance) Tirzepatide (Zepbound) uses a similar approach: Weeks 1-4: 2.5 mg Weeks 5-8: 5 mg Weeks 9-12: 7.5 mg Weeks 13-16: 10 mg Week 17+: 12.5 mg or 15 mg (if tolerated) Do not self-adjust doses

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however, NR supplementation did not alter cognitive functions