less side effects with tirzepatide 20 Possible Long-Term to Be Aware Of Multiple effects of tirzepatide. |

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PMID: 36 KrisanapanPSuppadungsukSSanpawithayakulKThongprayoonCPattharanitimaPTangpanithandeeSet al

Long-term oral supplement use, however, may cause cramping or bloating and could lower zinc levels

doi: 10.1136/jcp.2006.038976 115 ShinVYWuWKChuKMWongHPLamEKTaiEKet al

, Furthermore, while there was an increase in reports of suicidal ideation and depression in patients taking GLP-1 medications, there was no clear evidence that the GLP-1 medication was the cause

In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration