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When the skin starts to hurt, or turns a deeper purple color, doctors worry about something more serious

Based on observational data, a 2011 report highlighted an increased risk of pancreatitis and pancreatic cancer in patients using incretin therapy (Roshanov and Dennis, 2015)

Theyre expensive and they only work as long as youre taking them

Patients taking insulin or sulfonylureas alongside GLP-1 therapy should monitor blood glucose carefully due to increased hypoglycaemia risk and may require dose adjustments

Tirzepatide is not recommended for individuals with medullary thyroid carcinoma, MEN2, and certain health conditions such as pancreatitis and gallstones