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Discontinuation Rates Due to GI Adverse Events Stomach pain severe enough to cause participants to leave clinical trials is the most meaningful measure of GI tolerability

Some researchers exploring microdosing schedules suggest that doses as low as 1 to 2 mg weekly may provide measurable anti-inflammatory effects with minimal metabolic impact and side effects

Changes in the autonomic nervous system also play a role

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Meanwhile, evidence is mounting of the wider therapeutic benefits of GLP-1 drugs, with clinical trials ongoing for metabolic liver disease, cardiovascular diseases, chronic kidney disease, and neurological disorders, among others

Replace the pen cap and store the pen as directedrefrigerated if unopened, or at room temperature (below 30C) for up to 6 weeks once in use