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Both IDH1 and IDH2 enzymes utilize NADP + as their cofactor and generate NADPH via oxidative decarboxylation of isocitrate outside the context of the TCA cycle
Archived from the original on 17 March 2013
At the highest dose of 15mg, participants lost an average of 22.5% of their body weight over 72 weeks
Modeling from the Employee Benefit Research Institute shows that broader GLP1 coverage can increase employer health premiums by 6% to nearly 14% a year, even with costsharing in place
And its not even necessarily dose dependent as the 4mg arm was only a few points behind the high doses
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