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In de hersenen met name in de hypothalamus en de hersenstam benvloedt het de centra die verantwoordelijk zijn voor honger en verzadiging
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In an exploratory analysis of the results of the REWIND trial, a CVOT for dulaglutide (another once-weekly GLP-1RA), a highly significant reduction of 13%-14% was observed in the risk of substantive cognitive impairment, also after adjustment for baseline scores, age ,sex, ethnic origin or education [26]
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As a GLP-1 receptor agonist, semaglutide works by mimicking the incretin hormone GLP-1
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