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Results of the first phase 3 trial comparing orforglipron with oral semaglutide found that patients with diabetes lost on average 6-8% of their body weight with orforglipron, compared with 4-5% on semaglutide

Lpez-Cano C, Santos MD, Snchez E, Mart R, Bueno M, Gutirrez-Carrasquilla L, et al

Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed for type 2 diabetes management and, in some cases, weight management

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American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity