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AOD-9604 may also contribute indirectly by improving body composition, which can influence overall energy balance
It blocks an enzyme called NNMT, which helps control how cells use nicotinamide
These microbiome changes reversed rapidly, however, when the obese mice were returned to a normal, lean diet 79
Findings out of the 3000 people tested, 39% presented borderline or slightly deficient, 17% presented low levels and 9% were considered clinically deficient
However, some people dont get enough of this vitamin from their food
That claim holds mechanistically in cell and animal studies
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