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Emerging concerns: Recent reports have raised concerns about muscle and bone loss, a potential consequence of rapid weight loss, as well as the possibility of gastroparesis
While no clinically meaningful interaction is expected between these two medications , they work through entirely different mechanisms and are metabolised via separate pathways in the body
Other severe side effects shared by both medications include clay-colored stools and yellowing of the eyes or skin
The semaglutide group did have more reported GI complaints, such as nausea and diarrhea, but there was no difference in serious adverse events (and more deaths in the placebo group )
The two interventions are synergistic
A retrospective cohort study using the TriNetX dataset revealed a significant correlation between GLP-1 RAs use and elevated aspiration pneumonia risk in patients undergoing gastrointestinal endoscopy, particularly among those receiving propofol sedation [20]
