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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340
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Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating Gpx4 expression and inhibiting ferroptosis of nerve cells
195,196 Future research should elucidate the roles of SIRT1 in the microbiotaimmunemetabolism cross-pathways and evaluate its potential therapeutic synergy with microbiota-targeted interventions, including probiotics and dietary fibers
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Many individuals can resume modified activity during mid-phase, with progressive loading helping direct tissue remodeling along functional lines
