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Common reasons your GLP-1 is not working If youve been on a GLP-1 medication for months without seeing meaningful changes in your health or significant weight loss, youre likely wondering whats going on

The average is around 2 to 5kg over the transition years

In addition, the peptide was designed to selectively stimulate GH production in the anterior pituitary without affecting the production of other hormones, such as prolactin and ACTH, which are commonly triggered by other, less selective GHSs [8]

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When the body loses weight quickly, it can also lose muscle tissue