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In cell studies, folate deficiency upregulates miR-22 and miR-149
Endogenous examples include glutathione (-glutamyl-cysteinyl-glycine) and thioredoxin, both of which can effectively scavenge ROS such as hydroxyl radicals (OH), hydrogen peroxide, and peroxynitrite (ONOO - ) without enzymatic assistance
Notably, 1 O exihibits a high degree of chemical reactivity, allowing it to directly target lipids, proteins, and DNA in cell membranes, thereby inducing oxidative damage [88]
A role for insulin in diabetic neuropathy
Journal of Peptide Research, 2003
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