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Other side effects reported in the first month: Vomiting (around 20% of participants at higher doses) Decreased appetite (this is the intended effect, but it can feel extreme early on) Constipation or diarrhea Fatigue in the first 1 to 2 weeks Mild injection site reactions The glucagon component adds one side effect not seen with semaglutide or tirzepatide
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They amplify each other
PlexusDx providers can reduce your semaglutide dose, pause dose escalation, or transition you to a different formulationsuch as switching from injection to oral semaglutide, which some patients tolerate better due to lower peak blood levels
Is Retatrutide safe for long-term use
Storage and handling also differ slightly between the two
