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Vaccaro O, Masulli M, Nicolucci A et al (2017) Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

A year later, in August 2025, Forbes also hailed matcha for its cognitive, heart health, and antioxidant benefits

It can be an appealing option for people who have struggled to make progress with other treatments

Briefly, 20 mg mouse hippocampal tissue was broken and homogenized in 200 L ATP tissue lysate and centrifuged at 12,000 g for 5 min at 4 C to obtain the supernatant

However, because this is a new drug, long-term studies are still ongoing to understand its full safety profile, including any potential effects on cancer

References: Rosenstock J, Wysham C, Fras JP, et al