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Stacking & Combinations Because its mechanism is NAD+ preservation, the logical research pairing is with the NAD+ pathway : in some research framings, an NNMT inhibitor like 5-Amino-1MQ is discussed alongside NAD+ precursors, on the reasoning that inhibiting the enzyme that drains NAD+ and supplying more NAD+ substrate address the same bottleneck from two directions

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Additionally, if you're taking vitamin B12, some medicines can interfere with your ability to digest it, including: Aminosalicylic acid (Paser), used to treat digestive problems Colchicine (Colcrys, Mitigare, Gloperba) is an anti-inflammatory medicine used to prevent and treat gout Proton pump inhibitors (Prilosec, Prevacid) are used to reduce stomach acid Metformin (Glumetza, Fortamet, others), used to treat diabetes Vitamin C supplements QUESTION See Answer What are the warning signs of vitamin B12 deficiency