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Toxicol Lett 144:279288 James O, Lesna M, Roberts SH, Pulman L, Douglas AP, Smith PA, Watson AJ (1975) Liver damage after paracetamol overdose

Adv Pharmacol 38 : 205227

Due to the role played by GSH in regulating redox balance, some molecules involved in GSH metabolism, such as glutathione peroxidase 4 (GPX4), GCLC and the cystine transporter solute carrier family 7 member 11 (SLC7A11), have been reported to inhibit the ferroptosis of cancer cells 38,39,40,41,42,43,44

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It has indeed been shown that, when available for the host cells, GSH plays an important role in the protection of cells against oxygen radicals, detoxification and metabolisation of various endo- and exogenous compounds, cell cycle regulation, cell signaling and apoptosis 16,50,51,52