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On its own, this observation does not distinguish whether GPI linkage potentiates activity by fostering membrane association per se or by preventing diffusion of the ligand, which would reduce its local concentration

Clinical Cancer Research , 9 , 16281638

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A study published in Clinical Therapeutics found that oral semaglutide was more cost-effective than injectable semaglutide in more than 50% of the model simulations, offering similar health benefits at a lower cost