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It acts pro-angiogenically via VEGFR2: the peptide promotes VEGFR2 internalization and activates the VEGFR2-Akt-eNOS pathway, which is blocked by the endocytosis inhibitor Dynasore, and in preclinical models it increased vessel density as well as the restoration of blood flow in the ischemic rat hindlimb Hsieh et al., 2017

This short half-life is intentional

Wipe the chosen site with a 70% isopropyl alcohol swab and allow a full 30-second drying period before inserting the needle, eliminating surface pathogens

Address Deficiency: Prescribe medication if applicable from consultation

4a and Extended Data Fig

doi: 10.1007/s00726-008-0093-y