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Gene essentiality plot showing genes scores in untreated (x-axis) and ML210-treated (GPX4 inhibition) Karpas299 cells

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While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases

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