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The increased energy expenditure from glucagon activation may help preserve lean mass compared to approaches that rely primarily on appetite suppression, though this hypothesis requires further study

However, patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use Zepbound due to safety concerns

Patients were well balanced by age and by body mass index (BMI)

Even mild cold exposure, such as keeping indoor temperatures around 66 degrees Fahrenheit (19 degrees Celsius) or taking brief cold showers, can stimulate BAT activity

Based on relevance, three abstracts were screened, and two full texts were assessed

This mechanism helps reduce food intake naturally and effectively