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Predicts longevity

Given that ER can modulate miRNA profiles, it is plausible that ER could relieve repression of BDNF mRNA (e.g., by miR-206) by downregulating such miRNAs, thereby stabilizing the BDNF transcript [47]

Reported effects with this class include mild water retention, transient tingling or numbness in the hands, a brief flushing or head-rush sensation after injection, and increased hunger with some secretagogues

GLP-1 medications are (at least so far) approved for long-term use

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