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GST catalyzes reactions between GSH and toxic lipid aldehydes like 4-HNE, reinforcing the importance of maintaining GSH homeostasis in mitigating neurodegeneration (297)

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The phase 3b SOUL trial (NCT03914326) randomly assigned 9,650 patients of at least 50 years of age with type 2 diabetes and atherosclerotic vascular disease and/or chronic kidney disease 1:1 to oral semaglutide plus standard-of-care or a placebo plus standard-of-care

While traditional methods can be personalized, tesofensine offers a standardized approach that may have consistent effects across different individuals

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