Daver NG, Assi R, Kantarjian HM, Cortes JE, Ravandi F, Konopleva MY, Kadia TM, Borthakur G, Jabbour EJ, DiNardo CD, Velasquez M, Kelly M, Ning J, Nogueras Gonzlez GM, Pierce SA, Gombos D, Estrov ZE, Kornblau SM, Zhang W, Andreeff M
The increase in SAH levels is sufficient for sensitizing the liver and hepatocytes to tumor necrosis factor (TNF) cytotoxicity
In contrast, the metabolically impaired penumbra tissue may remain in a salvageable state if perfusion and cellular homeostasis are restored through appropriate therapeutic interventions [1, 3, 4]
Therefore, they suggested that the combination of nintedanib and first-line chemotherapy could significantly increase the PFS in advanced ovarian cancer
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