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Sorafenib is an FDA-approved drug for the treatment of patients with advanced HCC, and it has been confirmed to be a potential ferroptosis inducer
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It modulates the immunosuppressive tumor microenvironment by regulating non-immune cells (such as cancer-associated fibroblasts, endothelial cells, and adipose stromal cells), repolarizing tumor-associated macrophages, activating NK cells, and tuning cytokines
Mehta will order relevant investigations
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