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Autophagy and enhanced ASS1 expression are known to be associated with ADI-resistance [133, 144]

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This multi-modal approach makes it uniquely valuable for studying complex neurological conditions where multiple pathways are disrupted, and it crosses the blood-brain barrier via standard injectioneliminating the invasive delivery methods required by individual growth factors

The c-MET/HGF complex structure reveals that, by utilizing two distinct interfaces, one HGF molecule is sufficient to induce a specific dimerization mode of c-MET for receptor activation