The renal outcome was a composite of nephropathy, defined as the new onset of macroalbuminuria or a doubling of the serum creatinine level and an eGFR of 45 mL/min per 1.73 m2, the need for continuous renal replacement therapy, or death from renal disease
In blood plasma, Cu binds to ceruloplasmin, a transport protein that is a reactive protein of the acute phase
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SylvesterKGKastenbergZJMossRLEnnsGMCowanTMShawGMet al
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Tirzepatide operates through dual GLP-1 and GIP receptor agonism , a mechanism that already outperforms standalone GLP-1 drugs like semaglutide in head-to-head trials