Tirzepatide stimulates insulin secretion through the GIPR in human islets from healthy donors, supporting a role for GIPR agonism in its pharmacology (56)
Chlorpromazine, fluphenazine and aloperidol are also CYP2D6 inhibitors, but to a lesser extent
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These types of catalytic transformations could be broadly classified into oxidation and reduction, hydrogen transfer, bond cleavage, or cyclization reactions 6,7,8,9,10,11