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Wan J, Zhang X, Li Z, Mo F, Tang D, Xiao H, Wang J, Rong G, Liu T

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DSIP Mechanisms (What We Actually Know) Animal models show the following: Dose-dependent antinociceptive effects (pain reduction) Naloxone blockade, indicating opioid receptor involvement The effects on human subjects appear to be broader: Stress modulation Neurotransmitter regulation Possible circadian interaction The exact receptor targets remain undefined as of now, which means the optimal subcutaneous dose of DSIP has not been scientifically established

A non-judgemental, evidence-informed approach to these conversations will support better patient outcomes

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& Ho, J