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A striking and still unresolved observation is that the most vulnerable neuronal populations differ markedly across disorders, affecting distinct brain regions such as the hippocampus in AD, the substantia nigra in PD, or the motor cortex and spinal cord in ALS

Some practitioners advocate weight-based dosing (e.g., 2.5-5 g/kg daily), while others use fixed doses (250-500 g daily) regardless of body size

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