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Not for weight loss
These findings underscore the therapeutic potential of combined pharmaceutical strategies targeting both incretin systems and highlight contrasting results when looking at secondary endpoints compared to GLP-1R agonism alone
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Reduction of subjective sensation of fatigue
It is important to distinguish between direct pharmacological effects of semaglutide on sleep architecture and indirect effects mediated through weight loss, dietary changes, or other lifestyle modifications that often accompany weight management treatment
[11] [12] These cardiovascular benefits have influenced treatment algorithms, with guidelines recommending GLP-1 receptor agonists with proven cardiovascular benefit for patients with type 2 diabetes and atherosclerotic cardiovascular disease
