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The preliminary cardiovascular safety data for DPP-4 inhibitors are promising, and, if the results of long-term cardiovascular studies demonstrate reductions in hard cardiovascular end points, then this may consolidate the position of the DPP-4 inhibitors as the second-line choice for combination with metformin

J Biol Chem 276(49):4667146677 Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

[Abstract] Angew Chem Int Ed Engl

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Igwebuike UM, Ochiogu IS, Ihedinihu BC, Ikokide JE, Idika IK

The transition from perimenopause to menopause fundamentally changes the hormonal architecture that underpins our metabolism