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MCC950 treatment led to a rescue of 113.2% in CT COs and 116.5% in BD COs, indicating that MCC950 effectively restored activation levels beyond baseline in both groups, with a slightly greater effect in BD

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GBM cells (1 10 5 cells/well) were seeded on glass slides with a 0.2% gelatin coating (G-1890, Sigma Aldrich), until 80% of confluence and then fixed in 4% paraformaldehyde for 15 min at 4 C