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37 Regulation of the IL-23/Th17 pathway is another possible mechanism of the anti-inflammatory effects of GLP-1RAs
The data showing this translates into measurably better PCOS fertility outcomes pregnancy rate, live birth rate, egg-retrieval quality scores in IVF is suggestive in some smaller trials and underwhelming in others
doi: 10.1210/en.2010-0068 194 ToniN.TengE
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However, GLP-1 has a short half-life, which provides the desired impetus to develop analog compounds that can mimic its physiological functions
In this reporter assay, CYCA2;2 expression, noted in all tissues from the MZ to the EZ, was not affected by MTX treatment
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