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In both mice and humans, the frequency of dysfunctional CD8 + PD1 + T cells with impaired antitumor immunosurveillance capacity rises as MASH progresses (141)
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For controlled skin studies, topical application removes the confounders introduced by injection no injection site reactions, no systemic distribution diluting local concentration, no injection technique variability across research subjects
When the kidneys are functioning normally, there is very little or no albumin in the urine
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